I-FRANKFURT, eJamani-(I-WIRE YOSHISHINO)-Merz Therapeutics, inkokeli kwintsimi ye-neurotoxins kunye neshishini eliphantsi kweQela le-Merz, kunye ne-Teijin Pharma Limited, inkampani ephambili yeshishini lezempilo le-Teijin Group, ngokudibeneyo namhlanje babhengeze ukuba iTeijin Pharmaceuticals iphumelele. imvume evela kuMphathiswa wezeMpilo waseJapan, uMsebenzi kunye neNtlalontle (MHLW) ukusebenzisa i-Xeomin® (incobotulinumtoxinA) kwiiyunithi ze-50, i-100 okanye i-200 ye-injection ye-intramuscular yonyango lwe-spasms ephantsi.
I-spasm yamalungu angaphantsi yimpawu ye-upper motor neuron syndrome, ebonakaliswa ngokuyinhloko ngokunyuka kwethoni ye-muscle yamalungu kunye nokugqithisa okugqithisileyo kwe-streflex reflex njenge-sequelae ye-stroke.Iimpawu eziphambili zinobunzima bokuhamba ngokuqhelekileyo kunye nomngcipheko okhulayo wokuwa ngenxa ye-trunk engazinzanga, imisebenzi enzima okanye ephazamisayo kwimpilo yemihla ngemihla.Unyango oluqhelekileyo lwe-spasms yomlenze lubandakanya ukuvuselelwa komzimba kunye nokusetyenziswa kwezihlunu zomlomo zomlomo okanye i-neuromuscular blockers, njenge-botulinum toxin uhlobo A.
UStefan Brinkmann, iCEO yeMerz Therapeutics, uthe: “Ukwamkelwa okwandisiweyo kuphawula inyathelo elibalulekileyo kwiMerz Therapeutics kwaye sisiphumo sentsebenziswano yethu esondeleyo neTeijin Pharmaceuticals.Siyathemba ukuba amaqabane ethu azakwazisa ngempumelelo olu phawu lubalulekileyo lwe-spasticity koogqirha baseJapan kunye nezigulana. ”
UGqr Stefan Albrecht, iSekela likaMongameli we-Global R & D, i-Merz Therapeutics: "Olu lwandiso lweleyibhile eJapan ngomnye umzekelo obalaseleyo weenzuzo i-Xeomin ® ebonelela ngayo kwizigulane ezininzi ezine-post-stroke spasticity.Oogqirha ngoku banokukhetha ukunyanga i-spasticity esezantsi nangaphezulu, okanye banokuguquguquka njengoko kufuneka. Faka iidosi zomntu ngamnye ngononophelo.Siyazingca ngale mpumelelo, ngakumbi intsebenziswano ebalaseleyo neqabane lethu uTeijin. ”
UMongameli weTeijin Pharmaceutical u-Ichiro Watanabe uthe: "I-Teijin Pharmaceutical ibonelela ngamachiza ahlukeneyo, kubandakanywa unyango lwe-osteoporosis kunye nezixhobo zonyango, ezifana ne-sound wave ekhawulezileyo inkqubo yokuphulukisa i-fracture yezigulana ezinezifo ze-musculoskeletal.Ekuphenduleni utshintsho lwabantu kunye nokwandisa ulwazi lwezempilo , Siqalisa amachiza amatsha asebenzayo kunye nezisombululo, kubandakanywa nokuzaliseka koluntu oluzinzileyo.I-Teijin Pharmaceuticals iyaqhubeka ifaka isandla ekuphuculeni umgangatho wobomi (QOL) wezigulane ngokubonelela ngeendlela ezintsha zonyango lwezifo ezineemfuno ezingavumelekanga.”
I-Xeomin® iphatha ngokufanelekileyo i-peripheral cholinergic nerve endings ngokwenza buthathaka ukucutheka kwemisipha yokuzithandela, kwaye ikhulule ukuxinezeleka kwemisipha ngokuthintela ukukhutshwa kwe-neurotransmitter ebizwa ngokuba yi-acetylcholine.I-neurotoxin ecocwe kakhulu yeyona nto isebenzayo kuphela kwi-Xeomin®.Yenziwe ngokususa iiprotheyini eziyinkimbinkimbi kwi-toxin ye-A botulinum eveliswa yiClostridium botulinum usebenzisa iteknoloji yokucoca eyenziwe nguMerz Pharma GmbH & Co. KGaA.Ukungabikho kweeprotheni eziyinkimbinkimbi kuvumela i-Xeomin® ukunciphisa ukuveliswa kwee-antibodies ezinokuthi zinciphise ukusebenza.Uphuculo oluphawulekayo kumlinganiselo we-plantar flexor modified ashworth scale (MAS) wabonwa kwisigaba sesi-III solingo lwezonyango eJapan.
I-Xeomin® ihanjiswa yi-Merz Pharmaceuticals GmbH kumazwe angaphezu kwama-70 kwaye isetyenziselwa ukunyanga izigulane ezine-spasm yomlenze ophezulu, i-cervical dystonia, i-blepharospasm okanye i-salivation ngokugqithiseleyo.I-Teijin Pharmaceuticals isayine ilayisenisi eyodwa kunye nesivumelwano sophuhliso esidibeneyo se-Xeomin® eJapan kunye ne-Merz ngo-2017, kwaye yaqala ukuthengisa okukhethekileyo kwe-Xeomin® ngoDisemba ka-2020 emva kokufumana imvume kwi-Ofisi yoMphathiswa wezeMpilo, uMsebenzi kunye neNtlalontle (MHLW) yaseJapan.Ngokusekwe kwiSigaba sesi-Itu solingo lwezonyango lwe-Merz e-Japan, imvume esanda kufunyanwa eyongezelelweyo iye yatshintsha ezinye zezamkelo ezivunyiweyo.
Ngokuqhelekileyo, kubantu abadala, i-Xeomin® kufuneka ifakwe kwiimisipha ezininzi eziqinileyo.* Ubuninzi bedosi yolawulo luyiyunithi ye-400, kodwa kufuneka incitshiswe ngokufanelekileyo kwi-dose encinci ngokohlobo kunye nenani lemisipha ye-tonic ekujoliswe kuyo.Ukuba isiphumo sedosi yangaphambili siyancipha, phinda iidosi zivumelekile.Ixesha lokudosa kufuneka libe ziiveki ezili-12 okanye ngaphezulu, kodwa linokucuthwa libe ziiveki ezili-10 ngokuxhomekeke kwiimpawu.
* I-Myotonic: i-gastrocnemius (intloko ephakathi, intloko esecaleni), i-soleus, i-posterior tibialis, i-flexor digitorum longus, njl.
IMerz Therapeutics lishishini leMerz Pharmaceuticals GmbH elizinikele ekuphuculeni ubomi bezigulana kwihlabathi liphela.Ngophando lwayo olungaguqukiyo, uphuhliso kunye nenkcubeko entsha, iMerz Therapeutics izama ukuhlangabezana neemfuno zezigulane ezingafezekiyo kunye nokufezekisa iziphumo ezingcono.I-Merz Therapeutics ifuna ukuhlangabezana neemfuno ezizodwa zabantu abanengxaki yokunyakaza, izifo ze-neurological, izifo zesibindi, kunye nezinye iimeko zempilo ezichaphazela kakhulu umgangatho wobomi bezigulana.Ikomkhulu leMerz Therapeutics lihlala eFrankfurt, eJamani, lineeofisi zabameli kumazwe angaphezu kwama-90, kunye nesebe laseMntla Merika eRaleigh, kuMntla Carolina.I-Merz Pharmaceuticals GmbH yinxalenye yeQela le-Merz, inkampani yabucala yosapho ezinikele ekuphuhliseni izinto ezintsha ezihlangabezana neemfuno zezigulane kunye nabathengi ngaphezu kweminyaka eyi-110.
I-Teijin (ikhowudi ye-Tokyo Stock Exchange: 3401) liqela lehlabathi eliqhutywa ngeteknoloji elibonelela ngezisombululo eziphambili kwinkalo yexabiso lokusingqongileyo;ukhuseleko, ukhuseleko, kunye nokunciphisa iintlekele;ngokunjalo notshintsho lwabantu kunye nokwandisa ulwazi lwezempilo.I-Teijin yasekwa ngo-1918 njengomvelisi wokuqala we-rayon eJapan, kwaye ngoku iphuhliselwe kwishishini elikhethekileyo eligubungela iindawo ezintathu ezingundoqo zoshishino: izinto zokusebenza eziphezulu ezibandakanya i-aramid, i-carbon fiber kunye nezixhobo ezidibeneyo, kunye ne-resin kunye nokulungiswa kweplastiki, ifilimu. , i-polyester fiber kunye nokulungiswa kwemveliso;ukhathalelo lwezonyango, kubandakanywa amayeza kunye nezixhobo zempilo yasekhaya kwithambo / idibeneyo, inkqubo yokuphefumula, kunye nezifo ze-cardiovascular / metabolic, ukongikazi kunye nokunyamekela kwangaphambili;kunye ne-IT, kubandakanywa nezisombululo zonyango, zenkampani kunye ne-B2B kwiinkqubo zoluntu, kunye nesofthiwe epakishweyo kunye neenkonzo ze-intanethi ze-B2C zokuzonwabisa kwedijithali.Njengoko kuchazwe kwingxelo ye-brand "I-Chemistry yoLuntu, iziSombululo zoLuntu", iTeijin izimisele ngokunzulu kubachaphazelekayo bayo kwaye ijolise ekubeni yinkampani exhasa uluntu oluzayo.Eli qela liqulunqwe ziinkampani ezingaphezulu kwe-170 kwaye linabasebenzi abamalunga nama-20,000 kumazwe/iingingqi ezingama-20 kwihlabathi liphela.Kunyaka-mali ophela nge-31 kaMatshi ka-2021, uTeijin ubhengeze intengiso edibeneyo ye-836.5 yeebhiliyoni zee-yen (i-7.7 yeebhiliyoni zeedola) kunye nempahla ye-1.036.4 yeebhiliyoni zee-yen (i-9.5 yeebhiliyoni zeedola).
Ixesha lokuposa: Sep-10-2021